The One & Only Campaign

The One & Only Campaign is a public health effort, led by the Centers for Disease Control and Prevention (CDC) and the Safe Injection Practices Coalition (SIPC), to raise awareness among patients and healthcare providers about safe injection practices. The Campaign aims to eliminate infections resulting from unsafe injection practices. 


Since 2001, more than 150,000 patients in the United States have been notified of potential exposure to hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV due to lapses in basic infection control practices. Many of these lapses involved healthcare providers reusing syringes, resulting in contamination of medication vials or containers which were used then on subsequent patients. 
The goal of the One & Only Campaign is to ensure patients are protected each and every time they receive a medical injection. This will be attained by empowering patients and re-educating healthcare providers regarding safe injection practices. Targeted education and awareness campaigns focus on influencing the culture of patient safety. Patients and providers must both insist on nothing less than One Needle, One Syringe, Only One Time for each and every injection. This practice will greatly reduce the risk of contracting hepatitis and other infections through medical injection. The SIPC and One & Only Campaign are made possible by a CDC Foundation partnership with Eli Lilly and Company

Anticipated outcomes of the One & Only Campaign include:

  • Increased awareness among the general public and healthcare providers about safe injection practices;

  • Increased patient involvement/empowerment as a strategy to promote healthcare provider adherence to safe injection practices; and

  • Increased understanding and implementation of safe injection practices among healthcare providers.